A PI4KIIIβ inhibitor (IC50 = 19 nM); selective over PI4KIIIα and PI4KIIα; inhibits PI3K catalytic subunits (IC50s = 39

PIK-93 – 5 mg

Brand:
Cayman
CAS:
593960-11-3
Storage:
-20
UN-No:
Non-Hazardous - /

PIK-93 is an inhibitor of phosphatidylinositol 4-kinase IIIβ (PI4KIIIβ; IC50 = 19 nM).{14312} It is selective for PI4KIIIβ over PI4KIIIα and PI4KIIα (IC50s = 1,100 and >100,000 nM, respectively). However, it also inhibits the PI3K catalytic subunits (IC50s = 39, 590, 120, and 16 nM for p110α, p110β, p110δ, and p110γ, respectively). PIK-93 reduces enteroviral RNA replication when used at a concentration of 125 nM in HeLa cells.{36235} It also inhibits the transport of ceramide from the endoplasmic reticulum to the Golgi apparatus.{36236}  

 

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SKU: 10009212 - 5 mg Category:

Description

A PI4KIIIβ inhibitor (IC50 = 19 nM); selective over PI4KIIIα and PI4KIIα; inhibits PI3K catalytic subunits (IC50s = 39, 590, 120, and 16 nM for p110α, p110β, p110δ, and p110γ, respectively); reduces enteroviral RNA replication when used at a concentration of 125 nM in HeLa cells; inhibits intracellular ceramide transport

Formal name: N-[5-[4-chloro-3-[[(2-hydroxyethyl)amino]sulfonyl]phenyl]-4-methyl-2-thiazolyl]-acetamide

Synonyms: 

Molecular weight: 389.9

CAS: 593960-11-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Kinase Inhibitors|Other Lipid Kinases||Product Type|Biochemicals|Kinase Inhibitors|PI3K||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases||Research Area|Lipid Biochemistry|Glycerophospholipids|Phosphatidyl Inositol Kinases & Phosphatases||Research Area|Lipid Biochemistry|Lipid Transport||Research Area|Lipid Biochemistry|Sphingolipids

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