A potent inhibitor of the PI3K catalytic subunit p110δ (IC50s = 10

PIK-294 – 1 mg

Brand:
Cayman
CAS:
900185-02-6
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

PIK-294 is a potent inhibitor of the phosphatidylinositol 3-kinase (PI3K) catalytic subunit p110δ (IC50s = 10,000, 490, 10, and 160 nM, for p110 subunit isoforms α, β, δ, and γ, respectively).{14312} It is selective for PI3K p110 subunit isoforms over DNA-PK, mTOR, and eight tyrosine kinases tested.{17883} It inhibits chemokinetic and chemotactic migration of neutrophils induced by CXCL8 in a three-dimensional collagen gel migration assay.{41154}  

 

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SKU: 23427 - 1 mg Category:

Description

A potent inhibitor of the PI3K catalytic subunit p110δ (IC50s = 10,000, 490, 10, and 160 nM, for p110 subunit isoforms α, β, δ, and γ, respectively); selective for PI3K p110 subunit isoforms over DNA-PK, mTOR, and eight tyrosine kinases; inhibits chemokinetic and chemotactic migration of neutrophils induced by CXCL8

Formal name: 2-[[4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone

Synonyms: 

Molecular weight: 489.5

CAS: 900185-02-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PI3K||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling

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