An inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis

Pifithrin-α – 10 mg

Brand:
Cayman
CAS:
63208-82-2
Storage:
-20
UN-No:
Non-Hazardous - /

Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis.{17259} It prevents p53-mediated apoptosis induced by cytotoxic compounds in C8 cells at 10 μM {17259} and in human umbilical vein endothelial cells at 30 μM.{17260} Pifithrin-α can also protect cells from DNA damage-induced apoptosis by a p53-independent mechanism that might involve cyclin D1.{17261}  

 

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Description

An inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis, preventing p53-mediated apoptosis by cytotoxic compounds in C8 cells at 10 μM and in human umbilical vein endothelial cells at 30 μM

Formal name: 1-(4-methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)-ethanone, monohydrobromide

Synonyms:  PFT-α

Molecular weight: 367.3

CAS: 63208-82-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Transcription Factors|p53||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors

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