A synthetic dipeptide with immunomodulatory properties on both innate and adaptive immune responses in in vitro studies

Pidotimod – 10 g

Brand:
Cayman
CAS:
121808-62-6
Storage:
-20
UN-No:
Non-Hazardous - /

Pidotimod is a synthetic dipeptide with immunomodulatory properties on both innate and adaptive immune responses in in vitro studies.{30302} It has been shown to induce dendritic cell (DC) maturation, to upregulate the expression of HLA-DR and co-stimulatory molecules CD83 and CD86, to stimulate the release of pro-inflammatory molecules from DCs, which drives T cell proliferation and differentiation towards a Th1 phenotype, to enhance natural killer cell functions, to inhibit thymocyte apoptosis, and to promote phagocytosis.{30303} Through separate effects on ERK1/2 and NF-κB, pidotimod was shown to increase the expression of toll-like receptor 2 proteins. Pimotimod does not affect expression of ICAM-1 or the release of IL-8.{30303}  

 

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Description

A synthetic dipeptide with immunomodulatory properties on both innate and adaptive immune responses in in vitro studies

Formal name: 3-​[[(2S)​-​5-​oxo-​2-​pyrrolidinyl]​carbonyl]​​-4R-​thiazolidinecarboxyl​ic acid

Synonyms:  PGT/1A

Molecular weight: 244.3

CAS: 121808-62-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Peptides||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|Phagocytosis

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