A natural antagonist of GlyRs (IC50s = 57 and 117 µM for α1 and α2 homodimeric GlyRs

Picrotin – 25 mg

Brand:
Cayman
CAS:
21416-53-5
Storage:
-20
UN-No:
Non-Hazardous - /

Picrotin is a natural picrotoxane that antagonizes glycine receptors (GlyRs; IC50s = 57 and 117 µM for α1 and α2 homodimeric GlyRs, respectively).{33999,42440} It also inhibits α3 homodimeric GlyRs.{34001} Picrotin is inactive in inhibiting γ-aminobutyric acid (GABA) type A and type C receptors. Picrotin occurs in the natural plant-derived poison picrotoxin (Item No. 20771), equimolar with picrotoxinin.  

 

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Description

A natural antagonist of GlyRs (IC50s = 57 and 117 µM for α1 and α2 homodimeric GlyRs, respectively); does not inhibit GABAA or GABAC receptors

Formal name: (1aR,2aR,3S,6R,6aS,8aS,8bR,9S)-hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-3,6-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione

Synonyms: 

Molecular weight: 310.3

CAS: 21416-53-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Toxins||Research Area|Neuroscience

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