A flavonoid with diverse biological activities; decreases expression of FATP5 and SCD and inhibits free fatty acid-induced lipid accumulation in HepG2 cells at 10 µM; inhibits RANKL-induced osteoclast formation in isolated murine bone marrow cells and decreases the size of bone resorption pits in bovine bone slices; inhibits LPS-induced trabecular bone loss in a mouse model of inflammatory osteoporosis at 10 and 60 mg/kg; prevents ischemia-reperfusion-induced testicular apoptosis and MDA production in a rat model of testicular torsion; reduces airway inflammation

Picroside II – 50 mg

Brand:
Cayman
CAS:
39012-20-9
Storage:
-20
UN-No:
Non-Hazardous - /

Picroside II is a flavonoid that has been isolated from P. kurroa and has diverse biological activities.{52489,52490,52491,52492} It decreases expression of FATP5 and SCD, encoding fatty acid transport protein 5 and steroyl CoA desaturase, respectively, and inhibits free fatty acid-induced lipid accumulation in HepG2 cells when used at a concentration of 10 µM.{52489} Picroside II inhibits RANKL-induced osteoclast formation in isolated murine bone marrow cells and decreases the size of bone resorption pits in bovine bone slices.{52490} In vivo, picroside II (10 and 60 mg/kg) inhibits LPS-induced trabecular bone loss in a mouse model of inflammatory osteoporosis. It prevents ischemia-reperfusion-induced testicular apoptosis and malondialdehyde (MDA) production in a rat model of testicular torsion.{52491} Picroside II also reduces airway inflammation, lung mucus hypersecretion, and bronchoalveolar lavage fluid (BALF) inflammatory cell infiltration in a mouse model of house dust mite-induced allergic asthma.{52492}  

 

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SKU: 30319 - 50 mg Category:

Description

A flavonoid with diverse biological activities; decreases expression of FATP5 and SCD and inhibits free fatty acid-induced lipid accumulation in HepG2 cells at 10 µM; inhibits RANKL-induced osteoclast formation in isolated murine bone marrow cells and decreases the size of bone resorption pits in bovine bone slices; inhibits LPS-induced trabecular bone loss in a mouse model of inflammatory osteoporosis at 10 and 60 mg/kg; prevents ischemia-reperfusion-induced testicular apoptosis and MDA production in a rat model of testicular torsion; reduces airway inflammation, lung mucus hypersecretion, and BALF inflammatory cell infiltration in a mouse model of house dust mite-induced allergic asthma

Formal name: (1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-hexahydro-6-[(4-hydroxy-3-methoxybenzoyl)oxy]-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-ylβ-D-glucopyranoside

Synonyms:  Vanilloyl catalpol|Ampicoside

Molecular weight: 512.5

CAS: 39012-20-9

Purity: ≥98%

Formulation: A solid

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