A potent and selective inhibitor of IGF-1R (IC50 = 6 nM) causes cell cycle arrest and induces apoptosis in cancer cells both in vitro and in vivo

Picropodophyllotoxin – 5 mg

Brand:
Cayman
CAS:
477-47-4
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

Picropodophyllotoxin (PPP) is a potent and selective inhibitor of the insulin-like growth factor-1 receptor (IGF-1R), blocking the phosphorylation of artificial substrates with an IC50 value of 6 nM.{33633} It does not block substrate phosphorylation by insulin receptor, EGFR, FGFR, or PDGFR. PPP inhibits IGF-1R autophosphorylation (IC50 = ~1 nM), causes cell cycle arrest in G2/M phase, and induces apoptosis.{33633,33634} It is orally active and causes complete tumor regression in xenografted and allografted mice.{33633} Presumably through its effect on IGF-1R, PPP reduces VEGF expression and suppresses choroidal neovascularization in vivo.{33631}  

 

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Description

A potent and selective inhibitor of IGF-1R (IC50 = 6 nM) causes cell cycle arrest and induces apoptosis in cancer cells both in vitro and in vivo

Formal name: (5R,5aS,8aR,9R)-5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one

Synonyms:  AXL 1717|NSC 36407|Picropodophyllin|PPP

Molecular weight: 414.4

CAS: 477-47-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|IGF-1R/InsR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors

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