An adenosine A3 receptor agonist (Ki = 1.7 nM); selective for adenosine A3 over A1 and A2 receptors (Kis = 55.3 and 3

Piclidenoson – 10 mg

Brand:
Cayman
CAS:
152918-18-8
Storage:
-20
UN-No:
Non-Hazardous - /

Piclidenoson is an adenosine A3 receptor agonist (Ki = 1.7 nM).{52557} It is selective for adenosine A3 over A1 and A2 receptors (Kis = 55.3 and 3,099 nM, respectively). In vivo, piclidenoson (100 µg/kg) reduces wall thickening in a rabbit model of ischemia-reperfusion injury induced by coronary artery occlusion, an effect that can be reversed by the adenosine receptor antagonist 8-p-sulfophenyl theophylline.{52556} It reduces hepatocellular tumor growth, liver inflammation, and neuropathy in a rat model of bone-residing breast cancer and decreases the number of lung metastases in a model of metastatic murine melanoma.{52557} Piclidenoson (1 and 3 mg/kg) also reduces colonic inflammatory cell infiltration and damage in a mouse model of colitis induced by dextran sulfate (DSS; Item No. 23250) and in IL-10-/- mice.{52558}  

 

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Description

An adenosine A3 receptor agonist (Ki = 1.7 nM); selective for adenosine A3 over A1 and A2 receptors (Kis = 55.3 and 3,099 nM, respectively); reduces wall thickening in a rabbit model of ischemia-reperfusion injury induced by coronary artery occlusion at 100 µg/kg; reduces hepatocellular tumor growth, liver inflammation, and neuropathy in a rat model of bone-residing breast cancer and the number of lung metastases in a model of metastatic murine melanoma; reduces colonic inflammatory cell infiltration and damage in a mouse model of DSS-induced colitis and in in IL-10-/- mice at 1 and 3 mg/kg

Formal name: 1-deoxy-1-[6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-N-methyl-β-D-ribofuranuronamide

Synonyms:  CF-101|IB-MECA

Molecular weight: 510.3

CAS: 152918-18-8

Purity: ≥98%

Formulation: A crystalline solid

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