An inhibitor of PI3K p110α (IC50 = 2 nM in an enzyme assay); selective for p110α over p110β

PI3-Kinase α Inhibitor 2 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
1188890-32-5
Storage:
-20
UN-No:
Non-Hazardous - /

PI3-Kinase α (PI3Kα) inhibitor 2 is an inhibitor of PI3K p110α (IC50 = 2 nM in an enzyme assay).{14907} It is selective for p110α over p110β, p110γ, and PI3K C2β (IC50s = 16, 660, and 220 nM, respectively). It also inhibits mammalian target of rapamycin (mTOR; IC50 = 49 nM).{42914} PI3Kα inhibitor 2 inhibits proliferation in A375 melanoma cells with an IC50 value of 0.58 μM.{14907}  

 

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Description

An inhibitor of PI3K p110α (IC50 = 2 nM in an enzyme assay); selective for p110α over p110β, p110γ, and PI3K C2β (IC50s = 16, 660, and 220 nM, respectively); inhibits mTOR (IC50 = 49 nM); inhibits proliferation in A375 melanoma cells (IC50 = 0.58 μM)

Formal name: 3-[4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-phenol, dihydrochloride

Synonyms:  Phosphatidylinositol 3-Kinase α Inhibitor 2|PI3Kα Inhibitor 2

Molecular weight: 386.3

CAS: 1188890-32-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PI3K||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling

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