A degradation product of chlorophyll that is converted to phytanic acid

Phytol – 50 g

Brand:
Cayman
CAS:
150-86-7
Storage:
-20
UN-No:
Non-Hazardous - /

Phytol is a diterpene alcohol obtained from the degradation of chlorophyll and has been used in the synthesis of Vitamins E and K. During the digestion process of ruminants, phytol is liberated from chlorophyll and converted to phytanic acid (Item No. 90360) to be stored in fats. While humans cannot derive phytol from chlorophyll, free phytol, obtained from the consumption of ruminant adipose tissue and dairy products, is readily absorbed in the small intestine and converted to phytanic acid.{28384} Phytanic acid accumulates to toxic levels in a number of metabolic disorders, and the conversion of phytol to phytanic acid has been shown to be regulated via the activation of peroxisome proliferator-activated receptor α (PPARα).{28383,28384} Phytol and its metabolites have also been reported to activate retinoid X receptors (RXRs; Kis range from 2.3-67.2 µM) and to promote the activity of PPAR/RXR heterodimers.{28385,28383} Phytol also demonstrates sedative and anxiolytic effects through interaction with the GABAA receptor, and it has been explored as an antischistosomal agent in a mouse model of schistosomiasis.{28381,28382}  

 

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Description

A degradation product of chlorophyll that is converted to phytanic acid, which can accumulate to toxic levels in a number of metabolic disorders; activates RXRs (Kis range from 2.3-67.2 µM) and promotes the activity of PPAR/RXR heterodimers

Formal name: 3,7R,11R,15-tetramethyl-2E-hexadecen-1-ol

Synonyms:  trans-Phytol

Molecular weight: 296.5

CAS: 150-86-7

Purity: ≥85% (mixture of isomers)

Formulation: A neat oil

Product Type|Biochemicals|Antiparasitics|Anthelmintics||Product Type|Biochemicals|Ion Channel Modulation||Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Cofactors & Vitamins||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Endocrinology & Metabolism|Hormones & Receptors|RARs, RORs, & RXRs||Research Area|Endocrinology & Metabolism|Metabolic Diseases||Research Area|Infectious Disease|Parasitic Diseases||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety

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