A potent inhibitor of Aurora A kinase (IC50 = 31 nM); does not inhibit Aurora B kinase at doses up to 100 μM; inhibits the proliferation of HCT116

Phthalazinone pyrazole – 1 mg

Brand:
Cayman
CAS:
880487-62-7
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Three Aurora kinases, A-C, are involved in phosphorylation events that are critical for the completion of mitosis.{19817} Aurora A, involved in centrosomal assembly and acentrosomal spindle assembly, is overexpressed in many tumors.{19818} Phthalazinone pyrazole is a potent inhibitor of Aurora A kinase (IC50 = 31 nM).{19005} It does not inhibit Aurora B kinase at doses up to 100 μM.{19005} Phthalazinone pyrazole inhibits the proliferation of HCT116, COLO 205, and MCF-7 cells (IC50 = 7.8, 2.9, and 1.6 μM, respectively).{19005}  

 

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SKU: 10735 - 1 mg Category:

Description

A potent inhibitor of Aurora A kinase (IC50 = 31 nM); does not inhibit Aurora B kinase at doses up to 100 μM; inhibits the proliferation of HCT116, COLO 205, and MCF-7 cells (IC50 = 7.8, 2.9, and 1.6 μM, respectively)

Formal name: 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2H-phenyl-1-phthalazinone

Synonyms: 

Molecular weight: 317.4

CAS: 880487-62-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Aurora||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Aurora Signaling

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