A selective inhibitor of SHP-2 (IC50 = 2.1 µM; Ki = 0.73 µM); inhibits SHP-2-dependent cellular signaling and tumor cell colony formation

PHPS1 – 5 mg

Brand:
Cayman
CAS:
314291-83-3
Storage:
-20
UN-No:
Non-Hazardous - /

PHPS1 is a cell-permeable, phosphotyrosine mimetic that inhibits the Src homology region 2 domain-containing phosphatase (SHP)-2 (IC50 = 2.1 µM; Ki = 0.73 µM).{31309} It is selective for SHP-2, inhibiting ECPTP, PTP1B, SHP-1, and mycobacterium MptpA at relatively higher concentrations (IC50s = 5.4, 19, 30, and 39 µM, respectively).{31309} PHPS1 has been shown to inhibit SHP-2-dependent cellular signaling and tumor cell colony formation.{31309}  

 

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Description

A selective inhibitor of SHP-2 (IC50 = 2.1 µM; Ki = 0.73 µM); inhibits SHP-2-dependent cellular signaling and tumor cell colony formation

Formal name: 4-[2-[1,5-dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]-benzenesulfonic acid

Synonyms:  Phenylhydrazonopyrazolone sulfonate 1|Protein Tyrosine Phosphatase Inhibitor V|PTP Inhibitor V

Molecular weight: 465.4

CAS: 314291-83-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Cancer

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