A natural and potent inhibitor of NEP and NEP2

Phosphoramidon (sodium salt) – 1 mg

Brand:
Cayman
CAS:
164204-38-0
Storage:
-20
UN-No:
Non-Hazardous - /

Neprilysin (NEP) and NEP2 are membrane-bound zinc metalloproteases.{24074,24072} Phosphoramidon is a natural and potent inhibitor of NEP and NEP2, with Ki values of 2 nM for both enzymes.{24073,24074} It is also a weak inhibitor of the related zinc metalloprotease endothelin-converting enzyme (Ki = 3.5 µM).{24082} Phosphoramidon has little or no effect on a variety of other proteases, including trypsin, papain, chymotrypsin, pepsin, and angiotensin-converting enzyme.{24073}  

 

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Description

A natural and potent inhibitor of NEP and NEP2, with Ki values of 2 nM for both enzymes; also a weak inhibitor of the related zinc metalloprotease ECE (Ki = 3.5 µM); has little or no effect on a variety of other proteases

Formal name: N-[N-[[(6-deoxy-a-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan, disodium salt

Synonyms: 

Molecular weight: 589.5

CAS: 164204-38-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cell Biology|Proteolysis

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