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Phospholipase C β2 Polyclonal Antibody – 100 µl

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Cayman
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Phospholipase C β2 (PLCβ2) is an enzyme that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the secondary messengers inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG).{59155,59156} It is approximately 135 kDa and is composed of a pleckstrin homology domain, four EF-hand motifs, a catalytic domain, and a C2 domain that are common to all PLCs, as well as a 400-amino acid C-terminal region that is required for PLCβ2 activation by the G-protein subunits Gαq or Gα11.{59157} PLCβ2 is also activated by Gβγ subunits. Upon activation by a G-protein subunit, PLCβ2 initiates intracellular signal transduction of extracellular signals using calcium as a cofactor. PLCβ2 colocalizes with T1R and T2R taste receptors and Plcb2-/- mice exhibit selective and complete loss of sweet, amino acid, and bitter tastes.{59158} Plcb2-/- mice also exhibit increased coxsackievirus A16-induced pro-inflammatory cytokine production and decreased survival compared with wild-type mice.{59159} Cayman’s Phospholipase C β2 Polyclonal Antibody can be used for immunohistochemistry (IHC) and immunofluorescence (IF) applications.  

 

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SKU: 29290 - 100 µl Category:

Description

Immunogen: Peptide from the C-terminal region of human PLCβ2 • Host: Rabbit • Species Reactivity: (+) Human, Non-human Primate • Applications: IHC, IF • MW = ~135 kDa

Synonyms: 1-Phosphatidylinositol 4,5-bisphosphate Phosphodiesterase β2|Phosphoinositide Phospholipase C β2|PLCβ2

Immunogen: Peptide from the C-terminal region of human PLCβ2

Formulation: 100 µl of affinity-purified polyclonal antibody from pooled serum

Isotype:

Applications: IHC, IF

Origin:

Stability: 365 days

Application|Immunofluorescence||Application|Immunohistochemistry||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cell Biology||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases||Research Area|Lipid Biochemistry|Glycerophospholipids|Phospholipases

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