A mixture of bovine phosphatidylserines; comprises 2-10% of total phospholipids in mammals and is enriched in the brain; found mainly on the inner leaflet of the cell membrane; synthesized in the ER and mitochondria; is a precursor to phosphatidylcholine and phosphatidylethanolamine; cofactor for various signaling pathways; externalized during apoptosis as a signal for phagocytes to engulf the cell

Phosphatidylserines (bovine) – 50 mg

Brand:
Cayman
CAS:
1446756-47-3
Storage:
-20
UN-No:
Non-Hazardous - 1888 / 6.1

Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina.{38744} It is anionic and found mainly on the inner leaflet of the cell membrane. It is biosynthesized from phosphatidylcholine (Item Nos. 24343 | 24370) or phosphatidylethanolamine (Item No. 24332) by phosphatidyl synthase 1 (PSS1) or PSS2, respectively, in the endoplasmic reticulum and can be reversibly converted back by the same enzymes. It can also be irreversibly converted to phosphatidylethanolamine by phosphatidylserine decarboxylase in the mitochondria. Phosphatidylserine binds to T cell immunoglobulin mucin type 1 (TIM-1) and TIM-4 receptors as well as brain-specific angiogenesis inhibitor 1 (BAI1), leading to anti-inflammatory and anti-atherosclerotic effects.{38745} It is also a cofactor involved in the activation of various signaling pathways through activation of protein kinase C, neutral sphingomyelinase, and c-Raf-1 protein kinase among others.{38744} Phosphatidylserine is externalized during apoptosis by scramblases in the plasma membrane as a signal for phagocytes to engulf the cell.{38746} Phosphatidylserines (bovine) is a mixture of bovine phosphatidylserines containing fatty acids with variable chain lengths at the sn-1 and sn-2 positions. [Matreya, LLC. Catalog No. 1047]  

 

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SKU: 24341 - 50 mg Category:

Description

A mixture of bovine phosphatidylserines; comprises 2-10% of total phospholipids in mammals and is enriched in the brain; found mainly on the inner leaflet of the cell membrane; synthesized in the ER and mitochondria; is a precursor to phosphatidylcholine and phosphatidylethanolamine; cofactor for various signaling pathways; externalized during apoptosis as a signal for phagocytes to engulf the cell

Formal name:

Synonyms:  PtdSers (bovine)

Molecular weight: 788.1

CAS: 1446756-47-3

Purity: ≥98%

Formulation: A solution in chloroform

Product Type|Biochemicals|Lipids|Glycerophospholipids||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity|Phagocytosis||Research Area|Lipid Biochemistry|Glycerophospholipids

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