A mixture of phosphatidylethanolamines isolated from bovine brain; comprises approximately 25% of total mammalian phospholipids and almost 50% of brain phospholipids; found mainly in the cell membrane; synthesized mainly in the ER and mitochondrial membranes; acts as a chaperone in E. coli for lactose permease assembly; cofactor for prion propagation that can convert recombinant mammalian proteins into infectious molecules

Phosphatidylethanolamines (bovine) – 25 mg

Brand:
Cayman
CAS:
90989-93-8
Storage:
-20
UN-No:
Non-Hazardous - 1888 / 6.1

Phosphatidylethanolamine is the most abundant phospholipid in prokaryotes and the second most abundant found in the membrane of mammalian, plant, and yeast cells, comprising approximately 25% of total mammalian phospholipids.{24442} In the brain, phosphatidylethanolamine comprises almost half of the total phospholipids. It is synthesized mainly through the cytidine diphosphate-ethanolamine and phosphatidylserine decarboxylation pathways, which occur in the endoplasmic reticulum (ER) and mitochondrial membranes, respectively. It is a precursor in the synthesis of phosphatidylcholine and arachidonoyl ethanolamide (AEA; Item No. 90050) and is a source of ethanolamine used in various cellular functions. In E. coli, phosphatidylethanolamine deficiency prevents proper assembly of lactose permease, suggesting a role as a lipid chaperone.{41481} It is a cofactor in the propagation of prions in vitro and can convert recombinant mammalian proteins into infectious molecules even in the absence of RNA.{41480} Phosphatidylethanolamines (bovine) is a mixture of phosphatidylethanolamines isolated from bovine brain with various fatty acyl groups at the sn-1 and sn-2 positions. [Matreya, LLC. Catalog No. 1069]  

 

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Description

A mixture of phosphatidylethanolamines isolated from bovine brain; comprises approximately 25% of total mammalian phospholipids and almost 50% of brain phospholipids; found mainly in the cell membrane; synthesized mainly in the ER and mitochondrial membranes; acts as a chaperone in E. coli for lactose permease assembly; cofactor for prion propagation that can convert recombinant mammalian proteins into infectious molecules,,

Formal name:

Synonyms:  PE (bovine)

Molecular weight: 744

CAS: 90989-93-8

Purity: ≥98%

Formulation: A solution in chloroform

Product Type|Biochemicals|Lipids|Glycerophospholipids||Research Area|Cell Biology|Cellular Chaperones||Research Area|Lipid Biochemistry|Glycerophospholipids||Research Area|Neuroscience|Neurodegenerative Disorders|Prion Disease

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