An activator of PKC

Phorbol 12,13-dibutyrate – 5 mg

Brand:
Cayman
CAS:
37558-16-0
Storage:
-20
UN-No:
Non-Hazardous - /

Phorbol 12,13-dibutyrate is a phorbol ester and an activator of PKC, including group A (α and γ) and group B (δ, ε, η) PKC isoforms.{45312} It promotes tumor formation to a lesser degree than phorbol 12-myristate 13-acetate (TPA; Item No. 10008014).{45313} Phorbol 12,13-dibutyrate induces papilloma formation in mice with a total dose of 9.7 µmol required to produce papillomas in 50% of survivors after eight weeks.{45314} It also induces inflammation in 50% of mice when administered topically to the ear at a dose of 0.067 µmol/ear.  

 

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SKU: 27785 - 5 mg Category:

Description

An activator of PKC, including group A (α and γ) and group B (δ, ε, η) isoforms; induces papilloma formation in mice with a total dose of 9.7 µmol required to produce papillomas in 50% of survivors after eight weeks; induces inflammation in 50% of mice when administered topically to the ear at a dose of 0.067 µmol/ear

Formal name: Butanoic acid, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa[3,4]benz[1,2-e]azulene-9,9a-diyl ester

Synonyms:  PDBu

Molecular weight: 504.6

CAS: 37558-16-0

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Activators|Kinases||Research Area|Cancer|Cell Signaling|PKC Signaling||Research Area|Cell Biology|Cell Signaling||Research Area|Immunology & Inflammation

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