A phorbol ester that is commonly used to activate certain types of protein PKC and

Phorbol 12-myristate 13-acetate – 5 mg

Brand:
Cayman
CAS:
16561-29-8
Storage:
-20
UN-No:
Non-Hazardous - /

Phorbol 12-myristate 13-acetate (PMA) is a phorbol ester that is commonly used to activate certain types of protein kinase C (PKC), including group A (α, βI, βII, γ) and group B (δ, ε, η, θ) isoforms.{17804} Phorbol esters, including PMA, are structurally analogous to diacylglycerol and activate PKC isoforms by associating with their C1 domains.{17805} Through PKC, PMA also activates certain MAP kinase pathways.{17806} Prolonged treatment of cells with PMA at high concentrations results in the downregulation of total PKC activity and is tumorigenic, whereas lower concentrations may be protective.{17807,17808} In addition, PMA promotes hematopoietic differentiation.{17809,17810} The aqueous solubility of PMA is about 10-fold better than that of phorbol-12,13-dibutyrate, indicating that PMA is preferable in cell-based studies.  

 

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SKU: 10008014 - 5 mg Category:

Description

A phorbol ester that is commonly used to activate certain types of protein PKC and, indirectly, certain MAP kinase pathways; prolonged treatment with PMA produces various effects, ranging from tumorigenesis to hematopoietic differentiation

Formal name: tetradecanoic acid, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl ester

Synonyms:  12-O-Tetradecanoylphorbol-13-acetate|PMA|TPA

Molecular weight: 616.8

CAS: 16561-29-8

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Activators|Kinases||Research Area|Cancer|Cell Signaling|PKC Signaling||Research Area|Cell Biology|Cell Signaling||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity

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