A cyclic hexapeptide mycotoxin that binds β-tubulin in a vinca domain; blocks microtubule growth

Phomopsin A – 5 mg

Brand:
Cayman
CAS:
64925-80-0
Storage:
-20
UN-No:
Non-Hazardous - /

Phomopsins are a family of mycotoxins produced by the fungus D. toxica, which predominantly infects lupines. Ingestion of lupines infected with D. toxica causes lupinosis, a degenerative disorder that can result in acute liver damage, brain damage, and death.{31104} Phomopsin A is a cyclic hexapeptide mycotoxin that binds β-tubulin in a vinca domain, overlapping with the site targeted by vinblastine (Item No. 11762) and other tubulin inhibitors.{31105,31103} It binds β-tubulin from higher organisms but not α-tubulin or fungal mycelial tubulin.{31106,31107} Phomopsin A blocks microtubule growth, modulates the dynamics of microtubules, and interferes with mitosis.{31107}  

 

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Description

A cyclic hexapeptide mycotoxin that binds β-tubulin in a vinca domain; blocks microtubule growth, modulates the dynamics of microtubules, and interferes with mitosis

Formal name: (2E)-(βS)-3-chloro-β,5-dihydroxy-N-methyl-L-tyrosyl-3,4-didehydro-L-valyl-3-hydroxy-L-isoleucyl-3,4-didehydro-L-prolyl-(2E)-2,3-didehydroisoleucyl-2,3-didehydro-aspartic acid, cyclic (15→3)-ether

Synonyms:  NSC 381839

Molecular weight: 789.2

CAS: 64925-80-0

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Microtubule Dynamics||Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Toxins|Mycotoxins||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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