A natural product from the bark of apple trees that reduces plasma glucose levels by blocking renal and intestinal glucose absorption through competitive inhibition of SGLT1 and SGLT2; exhibits Ki values of 140 and 11 nM

Phlorizin – 5 g

Brand:
Cayman
CAS:
60-81-1
Storage:
-20
UN-No:
Non-Hazardous - /

Sodium-glucose cotransporter 1 (SGLT1) is a high affinity, low capacity transporter abundant in the small intestine, with some expression in the kidney as well. SGLT2 is a low affinity, high capacity transporter in the kidney that accounts for approximately 90% of glucose reabsorption into the blood stream. Selective inhibition of SGLT2 is a potential strategy for reducing plasma glucose levels as a treatment for diabetes.{20896} Phlorizin is a natural product, first isolated from the bark of apple trees, that reduces plasma glucose levels by blocking renal and intestinal glucose absorption through inhibition of SGLT1 and SGLT2.{20893,20892} It competitively inhibits the initial rate of α-methyl-D-glucopyranoside (α-MDG) uptake in human COS-1 cells expressing hSGLT1 and hSGLT2 with IC50 values of 400 and 65 nM, respectively.{20895} In HEK293T cells expressing human SGLT1 and SGLT2, phlorizin exhibits Ki values of 140 and 11 nM, respectively, at 37°C.{20895,20894}  

 

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Description

A natural product from the bark of apple trees that reduces plasma glucose levels by blocking renal and intestinal glucose absorption through competitive inhibition of SGLT1 and SGLT2; exhibits Ki values of 140 and 11 nM, respectively, at 37°C, for human SGLT1 and SGLT2, respectively

Formal name: 1-[2-(β-D-glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone

Synonyms:  Floridzin|NSC 2833

Molecular weight: 436.4

CAS: 60-81-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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