A natural phenol which inhibits the monocarboxylate transporters MCT1 and MCT2 (IC50 = 28 and 14 µM

Phloretin – 500 mg

Brand:
Cayman
CAS:
60-82-2
Storage:
-20
UN-No:
Non-Hazardous - /

Phloretin is a natural phenol which inhibits a variety of transporters. It inhibits the monocarboxylate transporters MCT1 and MCT2 (IC50 = 28 and 14 µM, respectively), restricting the rapid transport of monocarboxylates like lactate and pyruvate across the plasma membrane.{22891} Phloretin also blocks the sodium/D-glucose cotransporter (Ki = 86 µM) and the human concentrative nucleoside transporter 3 (Ki = 32 µM).{22894,22892}  

 

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Description

A natural phenol which inhibits the monocarboxylate transporters MCT1 and MCT2 (IC50 = 28 and 14 µM, respectively); also blocks the sodium/D-glucose cotransporter (Ki = 86 µM) and the human concentrative nucleoside transporter 3 (Ki = 32 µM)

Formal name: 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone

Synonyms:  NSC 407292|RJC 02792

Molecular weight: 274.3

CAS: 60-82-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Polyphenols||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism

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