A glycopeptide antibiotic that causes DNA fragmentation; used

Phleomycin – 25 mg

Brand:
Cayman
CAS:
11006-33-0
Storage:
-20
UN-No:
Non-Hazardous - /

Phleomycin is a glycopeptide antibiotic from Streptomyces whose cytotoxic action results from its ability to cause DNA fragmentation.{25379,21617} The ability of phleomycin to block mammalian cells from entering mitosis has made it useful in cancer therapy, most commonly in conjunction with other therapeutic modalities.{21617,25378,25377} Phleomycin is also used, in conjunction with a vector carrying the bleomycin resistance protein ble, as a selective agent in the transformation of yeast, plant cells, and mammalian cells.{25382,25381,25380}  

 

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Description

A glycopeptide antibiotic that causes DNA fragmentation; used, in conjunction with a vector carrying the bleomycin resistance protein ble, as a selective agent in the transformation of yeast, plant cells, and mammalian cells

Formal name: (2R,3S,4S,5R,6R)-2-(((2R,3S,4S,5S,6S)-2-(2-(6-amino-2-(3-amino-1-((2,3-diamino-3-oxopropyl)amino)-3-oxopropyl)-5-methylpyrimidine-4-carboxamido)-3-((5-((1-((2-(4-((4-guanidinobutyl)carbamoyl)-4′,5′-dihydro-[2,4′-bithiazol]-2′-yl)ethyl)amino)-3-hydroxy-1-oxobutan-2-yl)amino)-3-hydroxy-4-methyl-5-oxopentan-2-yl)amino)-1-(1H-imidazol-4-yl)-3-oxopropoxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl carbamate, copper(II) salt, monohydrochloride

Synonyms: 

Molecular weight: 1,525.50

CAS: 11006-33-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|DNA Damage and Repair

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