A lignan with diverse biological activities; reduces hydrogen peroxide-induced caspase activation

Phillyrin – 10 mg

Brand:
Cayman
CAS:
487-41-2
Storage:
-20
UN-No:
Non-Hazardous - /

Phillyrin is a lignan that has been found in F. suspense and has diverse biological activities.{48853,48854,48855,48856,48857} It reduces hydrogen peroxide-induced caspase activation, increases in malondialdehyde (MDA) levels, and production of reactive oxygen species (ROS), as well as increases glutathione peroxidase (GPX) and superoxide dismutase (SOD) activities in PC12 cells.{48853} Phillyrin is active against P. aeruginosa in vitro (MIC = 0.5 mg/ml) and increases survival in a C. elegans model of P. aeruginosa infection.{48854} Intragastric administration of phillyrin (10 and 20 mg/kg) reduces pulmonary NF-κB activation, neutrophil infiltration, and levels of TNF-α, IL-1β, and IL-6, as well as interstitial edema, in a mouse model of LPS-induced acute lung injury.{48855} It decreases body weight, hepatic total cholesterol, free fatty acid, and triglyceride levels, and serum insulin levels in obese mice.{48856} Phillyrin (20 mg/kg) also prolongs survival time, decreases viral titers, and attenuates pulmonary tissue damage in a mouse model of influenza A infection.{48857}  

 

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SKU: 29654 - 10 mg Category:

Description

A lignan with diverse biological activities; reduces hydrogen peroxide-induced caspase activation, increases in MDA levels, and production of ROS, as well as increases GPX and SOD activities in PC12 cells; active against P. aeruginosa in vitro (MIC = 0.5 mg/ml); increases survival in a C. elegans model of P. aeruginosa infection; intragastric administration reduces pulmonary NF-κB activation, neutrophil infiltration, and levels of TNF-α, IL-1β, and IL-6, as well as interstitial edema in a mouse model of LPS-induced acute lung injury at 10 and 20 mg/kg; decreases body weight, hepatic total cholesterol, free fatty acid, and triglyceride levels, and serum insulin levels in obese mice; prolongs survival time, decreases viral titers, and attenuates pulmonary tissue damage in a mouse model of influenza A infection at 20 mg/kg

Formal name: 4-[(1S,3aR,4R,6aR)-4-(3,4-dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-2-methoxyphenyl, β-D-glucopyranoside

Synonyms: 

Molecular weight: 534.6

CAS: 487-41-2

Purity: ≥98%

Formulation: A solid

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