Description
A lignan with diverse biological activities; scavenges peroxide and DPPH radicals in cell-free assays (IC50s = 10.5 and 19.1 µM, respectively); inhibits LPS-induced production of IL-1β, IL-6, TNF-α, and the fibrosis markers collagen I and α-SMA in LX-2 hepatic stellate cells from 25-200 µg/ml; inhibits the growth of SH-1-V1 esophageal cancer cells (IC50 = 6 µM), as well as induces the production of ROS and apoptosis in the same cells; reduces tumor volume in an SH-1-V1 mouse xenograft model at 15 mg/kg; reduces serum levels of ALT, AST, SOD, and MDA and prevents hepatic necrosis in a mouse model of carbon tetrachloride-induced liver injury
Formal name: 4-[(1S,3aR,4R,6aR)-4-(3,4-dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-2-methoxy-phenol
Synonyms: (+)-Phillygenin|Epipinoresinol methyl ether
Molecular weight: 372.4
CAS: 487-39-8
Purity: ≥95%
Formulation: A crystalline solid
