A lignan with diverse biological activities; scavenges peroxide and DPPH radicals in cell-free assays (IC50s = 10.5 and 19.1 µM

Phillygenin – 10 mg

Brand:
Cayman
CAS:
487-39-8
Storage:
-20
UN-No:
Non-Hazardous - /

Phillygenin is a lignan that has been found in F. fructus and has diverse biological activities.{56162,56063,56164,56165} It scavenges peroxide and 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in cell-free assays (IC50s = 10.5 and 19.1 µM, respectively).{56162} Phillygenin (25-200 µg/ml) inhibits LPS-induced production of IL-1β, IL-6, TNF-α, and the fibrosis markers collagen I and α-SMA in LX-2 hepatic stellate cells.{56063} It inhibits the growth of SH-1-V1 esophageal cancer cells (IC50 = 6 µM), as well as induces the production of reactive oxygen species (ROS) and apoptosis in the same cells.{56164} Phillygenin (15 mg/kg) reduces tumor volume in an SH-1-V1 mouse xenograft model. It also reduces serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), superoxide dismutase (SOD), and malondialdehyde (MDA) and prevents hepatic necrosis in a mouse model of carbon tetrachloride-induced liver injury.{56165}  

 

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Description

A lignan with diverse biological activities; scavenges peroxide and DPPH radicals in cell-free assays (IC50s = 10.5 and 19.1 µM, respectively); inhibits LPS-induced production of IL-1β, IL-6, TNF-α, and the fibrosis markers collagen I and α-SMA in LX-2 hepatic stellate cells from 25-200 µg/ml; inhibits the growth of SH-1-V1 esophageal cancer cells (IC50 = 6 µM), as well as induces the production of ROS and apoptosis in the same cells; reduces tumor volume in an SH-1-V1 mouse xenograft model at 15 mg/kg; reduces serum levels of ALT, AST, SOD, and MDA and prevents hepatic necrosis in a mouse model of carbon tetrachloride-induced liver injury

Formal name: 4-[(1S,3aR,4R,6aR)-4-(3,4-dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-2-methoxy-phenol

Synonyms:  (+)-Phillygenin|Epipinoresinol methyl ether

Molecular weight: 372.4

CAS: 487-39-8

Purity: ≥95%

Formulation: A crystalline solid

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