A subtype-selective AMPA receptor antagonist that inhibits homomeric GluR1 and GluR3 as well as heteromeric GluR1/2 receptors (80-100% of glutamate-evoked currents inhibited at 100 µM); inhibits the GluR5(Q) receptor with a Ki value of 0.29 µM

Philanthotoxin 74 (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
1227301-51-0
Storage:
22
UN-No:
Non-Hazardous - /

Philanthotoxin 74 (PhTx-74) is a synthetic analog of the naturally-occurring wasp venom toxin philanthotoxin-4,3,3. It is a subtype-selective AMPA receptor antagonist that inhibits homomeric GluR1 and GluR3 as well as heteromeric GluR1/2 receptors (80-100% of glutamate-evoked currents inhibited at 100 µM). It exhibits minimal to no effect on monomeric GluR2 or heteromeric GluR2/3 receptors at concentrations up to 500 µM.{23500} PhTx-74 inhibits the GluR5(Q) receptor with a Ki value of 0.29 µM.{23501}  

 

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Description

A subtype-selective AMPA receptor antagonist that inhibits homomeric GluR1 and GluR3 as well as heteromeric GluR1/2 receptors (80-100% of glutamate-evoked currents inhibited at 100 µM); inhibits the GluR5(Q) receptor with a Ki value of 0.29 µM

Formal name: N-[7-[(4-aminobutyl)amino]heptyl]-4-hydroxy-αS-[(1-oxobutyl)amino]-benzenepropanamide, dihydrochloride

Synonyms:  PhTx-74

Molecular weight: 507.5

CAS: 1227301-51-0

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience

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