A product of chlorophyll breakdown that has been used as a photosensitizer in photodynamic therapy for the treatment of cancer; inhibits glioblastoma cell growth (IC50 = 2.8 µg/ml) and displays antiproliferative activity against melanoma

Pheophorbide a – 50 mg

Brand:
Cayman
CAS:
15664-29-6
Storage:
-20
UN-No:
Non-Hazardous - /

Pheophorbide a is a product of chlorophyll breakdown that has been used as a photosensitizer in photodynamic therapy for the treatment of cancer.{26143} It has been reported to inhibit U87MG cells with an IC50 value of 2.8 µg/ml and demonstrates cytostatic activity specifically against glioblastoma cells without affecting normal cells.{26144} It also displays antiproliferative activity against melanoma, breast, and lung cancer cells in vitro at 100 µg/ml.{26145}  

 

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Description

A product of chlorophyll breakdown that has been used as a photosensitizer in photodynamic therapy for the treatment of cancer; inhibits glioblastoma cell growth (IC50 = 2.8 µg/ml) and displays antiproliferative activity against melanoma, breast, and lung cancer cells in vitro at 100 µg/ml

Formal name: 9-ethenyl-14-ethyl-21R-(methoxycarbonyl)-4S,8,13,18-tetramethyl-20-oxo-3S-phorbinepropanoic acid

Synonyms:  2-Deacetyl-2-vinylbacteriopheophorbide

Molecular weight: 592.7

CAS: 15664-29-6

Purity: ≥90% (mixture of diastereomers)

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Research Area|Cancer

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