A hydantoin anticonvulsant; inhibits voltage-gated sodium channels in a voltage-dependent manner; suppresses the persistent sodium current in a dose-dependent manner (10-100 μM) in neurons isolated from rat neocortex; reduces seizure frequency and duration by 46 and approximately 20%

Phenytoin – 250 g

Brand:
Cayman
CAS:
57-41-0
Storage:
4
UN-No:
Non-Hazardous - /

Phenytoin is a hydantoin anticonvulsant.{38720} It inhibits voltage-gated sodium channels in a voltage-dependent manner.{38721} Phenytoin reduces neuron firing in response to a depolarizing current in neurons from crayfish, Aplysia, rats, and mice when used at concentrations ranging from 20 to 100 μM. It also suppresses the persistent sodium current in a dose-dependent manner in rat neocortex without affecting the voltage-dependence of current activation.{38722} Phenytoin is oxidized by cytochrome P450 into several products that can lead to cell death in vitro and toxic effects in vivo, such as gingival hyperplasia and teratogenicity in rats and mice, respectively.{38720} In a rat model of status epilepticus, administration of phenytoin over 7 days (75 mg/kg, i.p., the first day, then 50 mg/kg per day) reduces seizure frequency and duration by 46 and approximately 20%, respectively, during the treatment period.{38723} In combination with the P-glycoprotein inhibitor tariquidar, phenytoin reduces seizure frequency by 93% but only for the first three days of the treatment period. Formulations containing phenytoin have been used in the treatment of status epilepticus.  

 

Available on backorder

Add to quotes
SKU: 24037 - 250 g Category:

Description

A hydantoin anticonvulsant; inhibits voltage-gated sodium channels in a voltage-dependent manner; suppresses the persistent sodium current in a dose-dependent manner (10-100 μM) in neurons isolated from rat neocortex; reduces seizure frequency and duration by 46 and approximately 20%, respectively, when administered over 7 days (75 mg/kg, i.p., the first day, then 50 mg/kg per day) in a rat model of status epilepticus; oxidized by cytochrome P450 into products that can lead to cell death in vitro and toxic effects in vivo, such as gingival hyperplasia and teratogenicity in rats and mice, respectfully

Formal name: 5,5-diphenyl-2,4-imidazolidinedione

Synonyms:  5,5-Diphenylhydantoin|NSC 8722

Molecular weight: 252.3

CAS: 57-41-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience|Seizure Disorders

Related products

  • A potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM; also inhibits Cdk7/cyclin H

    (R)-Roscovitine – 10 mg

    Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.{14988} It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.{14987,14988,14991} (R)-Roscovitine inhibits the growth of rapidly proliferating cells with an average IC50 value of 15.2 µM against a panel of 19 human tumor cell lines.{14988} In murine models of polycystic kidney disease, (R)-roscovitine effectively inhibited disease progression at doses of 50-100 mg/kg.{14564}  

     

    Brand:
    Cayman
    SKU:10009569 - 10 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • PtdIns-(3

    PtdIns-(3,4,5)-P3-biotin (sodium salt) – 25 µg

    The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.  

     

    Brand:
    Cayman
    SKU:10009531 - 25 µg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state; activity is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM

    SC-1 – 1 mg

    The maintenance of embryonic stem cells in culture typically requires feeder cells and various exogenous factors found in serum. Murine embryonic stem (mES) cells can be maintained in the absence of feeder cells and serum but require the leukemia inhibitor factor (LIF) and bone morphogenic protein (BMP) to prevent differentiation and promote self-renewal. SC-1 is a small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state.{14533} The activity of SC-1 is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively.{14533} Inhibition of RasGAP increases Ras signaling via the PI3-kinase pathway which promotes self-renewal, whereas inhibition of ERK blocks differentiation.  

     

    Brand:
    Cayman
    SKU:10009557 - 1 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state; activity is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM

    SC-1 – 25 mg

    The maintenance of embryonic stem cells in culture typically requires feeder cells and various exogenous factors found in serum. Murine embryonic stem (mES) cells can be maintained in the absence of feeder cells and serum but require the leukemia inhibitor factor (LIF) and bone morphogenic protein (BMP) to prevent differentiation and promote self-renewal. SC-1 is a small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state.{14533} The activity of SC-1 is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively.{14533} Inhibition of RasGAP increases Ras signaling via the PI3-kinase pathway which promotes self-renewal, whereas inhibition of ERK blocks differentiation.  

     

    Brand:
    Cayman
    SKU:10009557 - 25 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page