An anticoagulant and vitamin K antagonist; inhibits the reduction of vitamin K1 epoxide to vitamin K1 by vitamin K1 epoxide reductase in liver homogenates in a concentration-dependent manner; inhibits prothrombin synthesis and conversion of vitamin K1 epoxide to vitamin K1 in rats by 50 and 57%

Phenindione – 250 mg

Brand:
Cayman
CAS:
83-12-5
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Phenindione is an anticoagulant and vitamin K antagonist.{52373,52375} It inhibits the reduction of vitamin K1 epoxide to vitamin K1 by vitamin K1 epoxide reductase in rat liver homogenates in a concentration-dependent manner.{52373} In vivo, phenindione (500 mg/kg) inhibits prothrombin synthesis and conversion of vitamin K1 epoxide to vitamin K1 in rats by 50 and 57%, respectively. Dietary administration of phenindione (4 mg/kg per day) inhibits aortic atherosclerosis or intracardial thrombosis in rat models of diet-induced atherosclerosis or intravascular thrombosis, respectively.{52375}  

 

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SKU: 30060 - 250 mg Category:

Description

An anticoagulant and vitamin K antagonist; inhibits the reduction of vitamin K1 epoxide to vitamin K1 by vitamin K1 epoxide reductase in liver homogenates in a concentration-dependent manner; inhibits prothrombin synthesis and conversion of vitamin K1 epoxide to vitamin K1 in rats by 50 and 57%, respectively, at 0.5 mg/100 g; dietary administration inhibits aortic atherosclerosis or intracardial thrombosis in rat models of diet-induced atherosclerosis or intravascular thrombosis, respectively, at 4 mg/kg per day

Formal name: 2-phenyl-1H-indene-1,3(2H)-dion

Synonyms:  2-Phenyl-1,3-Indandione|2-Phenylindandione|NSC 41693|Phenylindandione

Molecular weight: 222.2

CAS: 83-12-5

Purity: ≥98%

Formulation: A crystalline solid

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