Biguanide derivative that improves insulin sensitivity and decrease insulin resistance by inhibiting complex 1 of the mitochondrial respiratory chain and inducing AMPK-dependent signaling; inhibits peripheral glucose oxidation

Phenformin (hydrochloride) – 100 g

Brand:
Cayman
CAS:
834-28-6
Storage:
-20
UN-No:
Non-Hazardous - /

Phenformin is an orally administered biguanide derivative with potential to lower blood glucose concentrations in patients with non-insulin-dependent diabetes mellitus.{21398} In general, biguanides improve insulin sensitivity and decrease insulin resistance by inhibiting complex 1 of the mitochondrial respiratory chain and inducing AMP-activated protein kinase (AMPK)-dependent signaling.{21401,21403} Phenformin, however, has been withdrawn from clinical use because it also inhibits peripheral glucose oxidation and has an associated effect of inducing lactic acidosis when not metabolized sufficiently.{21398} Through AMPK activation, phenformin at 300 mg/kg exhibits anticancer activity by inhibiting the growth of MCF-7 and MDAMB231 breast cancer cell xenografts in mice.{24105}  

 

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Description

Biguanide derivative that improves insulin sensitivity and decrease insulin resistance by inhibiting complex 1 of the mitochondrial respiratory chain and inducing AMPK-dependent signaling; inhibits peripheral glucose oxidation, has an associated effect of inducing lactic acidosis when not metabolized sufficiently, and exhibits anticancer activity via AMPK activation

Formal name: N-(2-phenylethyl)-imidodicarbonimidic diamide, monohydrochloride

Synonyms: 

Molecular weight: 241.7

CAS: 834-28-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Kinases||Research Area|Cancer|Cell Signaling||Research Area|Cancer|Metabolism||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Nutrient Sensing

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