An inhibitor of MAO (IC50 = 0.9 μM using rat brain mitochondrial preparations); potentiates the effects of tryptamine on isolated rat fundus (EC50 = 90 nM) and increases tryptamine toxicity in mice (LD50s = 85 and 500 mg/kg in the presence and absence of phenelzine

Phenelzine (sulfate) – 250 mg

Brand:
Cayman
CAS:
156-51-4
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Phenelzine is an inhibitor of monoamine oxidase (MAO; IC50 = 0.9 μM using rat brain mitochondrial preparations).{38498} It potentiates the effects of tryptamine on isolated rat fundus (EC50 = 90 nM) and increases tryptamine toxicity in mice with LD50 values of 85 and 500 mg/kg in the presence and absence of phenelzine, respectively. Phenelzine (20 mg/kg) increases GABA, dopamine, serotonin (5-HT; Item No. 14332), and norepinephrine levels in the hippocampus and cortex of socially isolated rats and rats treated with the NMDA receptor antagonist (+)-MK-801 (Item No. 10009019).{38499} It also increases 5-HT levels in the ventral horn of the spinal cord, improves gross motor ability in a rotarod test, and increases locomotor activity in an open field test in mice with experimental autoimmune encephalomyelitis when administered at a dose of 30 mg/kg.{38500}  

 

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SKU: 23956 - 250 mg Category:

Description

An inhibitor of MAO (IC50 = 0.9 μM using rat brain mitochondrial preparations); potentiates the effects of tryptamine on isolated rat fundus (EC50 = 90 nM) and increases tryptamine toxicity in mice (LD50s = 85 and 500 mg/kg in the presence and absence of phenelzine, respectively); increases GABA, dopamine, 5-HT, and norepinephrine levels in the hippocampus and cortex of socially isolated rats and rats treated with the NMDA receptor antagonist (+)-MK-801 when administered at a dose of 20 mg/kg; increases 5-HT levels in the ventral horn of the spinal cord, improves gross motor ability in a rotarod test, and increases locomotor activity in an open field test in mice with experimental autoimmune encephalomyelitis when administered at a dose of 30 mg/kg,

Formal name: (2-phenylethyl)-hydrazine, monosulfate

Synonyms:  NSC 170957|W-1544A

Molecular weight: 234.3

CAS: 156-51-4

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Neuroscience|Behavioral Neuroscience

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