A broad-spectrum bacterial efflux pump inhibitor; potentiates the activity of levofloxacin against P. aeruginosa strains overexpressing the MexAB-OprM

Phe-Arg-βNA (hydrochloride) – 250 mg

Brand:
Cayman
CAS:
100929-99-5
Storage:
-20
UN-No:
Non-Hazardous - /

Phe-Arg-βNA is a peptide broad-spectrum bacterial efflux pump inhibitor.{53463} It potentiates the activity of the fluoroquinolone antibiotic levofloxacin (Item No. 20382) against P. aeruginosa strains overexpressing the MexAB-OprM, MexCD-OprJ, or MexEF-OprN multidrug resistance efflux pumps (EC50s = 10 µg/ml for all) but is inactive against these strains when used alone (MICs = >512 µg/ml for all). Phe-Arg-βNA also increases the susceptibility of quinolone-resistant E. coli isolates to nalidixic acid (Item No. 19807).{53464}  

 

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SKU: 29511 - 250 mg Category:

Description

A broad-spectrum bacterial efflux pump inhibitor; potentiates the activity of levofloxacin against P. aeruginosa strains overexpressing the MexAB-OprM, MexCD-OprJ, or MexEF-OprN multidrug resistance efflux pumps (EC50s = 10 µg/ml for all); increases the susceptibility of quinolone-resistant E. coli isolates to nalidixic acid

Formal name: L-phenylalanyl-N-2-naphthalenyl-L-argininamide, dihydrochloride

Synonyms: 

Molecular weight: 519.5

CAS: 100929-99-5

Purity: ≥98%

Formulation: A solid

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