An ATP-competitive inhibitor of Cdks that most potently inhibits Cdk2/cyclin A (IC50 = 45 nM); more than 3-fold less potent at Cdks 1

PHA-848125 – 10 mg

Brand:
Cayman
CAS:
802539-81-7
Storage:
-20
UN-No:
De Minimis - 3077 / 9

PHA-848125 is an ATP-competitive inhibitor of cyclin-dependent kinases (Cdks) that potently inhibits Cdk2/cyclin A (IC50 = 45 nM).{34455} It is at least 3-fold less potent at Cdks 1, 3, 4, 5, and 7.{34455} PHA-848125 is orally available and displays efficacy in suppressing the growth of cancer cells or tumor xenografts in animals.{34455,34456,34457}  

 

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Description

An ATP-competitive inhibitor of Cdks that most potently inhibits Cdk2/cyclin A (IC50 = 45 nM); more than 3-fold less potent at Cdks 1, 3, 4, 5, and 7

Formal name: 4,5-dihydro-N,1,4,4-tetramethyl-8-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

Synonyms:  Milciclib

Molecular weight: 460.6

CAS: 802539-81-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|CDKs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Signaling

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