Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes and activate PMNL.{8499} Many of these substances were recently isolated and purified from oxLDL

PGPC – 5 mg

Brand:
Cayman
CAS:
89947-79-5
Storage:
-20
UN-No:
De Minimis - 1170 / 3

PGPC is an oxidized phospholipid that can be formed under conditions of oxidative stress.{15289} It is found as a component in mildly oxidized LDL (MM-LDL) and in products formed from the oxidation of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (Ox-PAPC).{10395} PGPC activates peroxisome proliferator-activated receptor (PPARα) in a concentration-dependent manner in a cell-based ligand-binding assay.{37721} It increases VCAM1 and E-selectin expression in human aortic endothelial cells (HAECs), as well as HAEC binding by monocytes and polymorphonuclear neutrophils (PMNs), in a concentration-dependent manner.{10396} PGPC (37.5 μM) also increases total 5-lipoxygenase metabolites in murine resident peritoneal macrophages (RPMs) and induces apoptosis in A7r5 rat aortic smooth muscle cells in vitro when used at a concentration of 50 μM.{37717,37718} PGPC levels are increased in the serum, LDL, and peripheral blood mononuclear cells (PBMCs) of patients with coronary artery disease.{37719} UVA irradiation increases PGPC levels in cultured human skin fibroblasts.{37720}  

 

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SKU: 10044 - 5 mg Category:

Description

Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes and activate PMNL.{8499} Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position.{9891} One of these substances An oxidized phospholipid found as a component in MM-LDL and in products of Ox-PAPC; activates PPARα in a concentration-dependent manner; increases VCAM1 and E-selectin expression in HAECs, as well as HAEC binding by monocytes and PMNs, in a concentration-dependent manner; increases total 5-lipoxygenase metabolites in murine RPMs at 37.5 μM; induces apoptosis in A7r5 rat aortic smooth muscle cells in vitro at 50 μM; levels are increased in the serum, LDL, and PBMCs of patients with coronary artery disease; UVA irradiation increases PGPC levels in cultured human skin fibroblasts

Formal name: 1-palmitoyl-2-glutaryl phosphatidylcholine

Synonyms:  1-Hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine|1-Palmitoyl-2-glutaryl phosphatidylcholine|1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine

Molecular weight: 609.7

CAS: 89947-79-5

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Glycerophospholipids||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Cardiovascular Diseases|Coronary Artery Disease||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Cardiovascular System|Vasculature|Smooth Muscle Cells||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Lipid Biochemistry|Glycerophospholipids||Research Area|Lipid Biochemistry|Reactive O2/N2 Pathways||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation

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