A PFKFB3 inhibitor (IC50 = 137 nM for human recombinant PFKFB3); inhibits PFKFB3 and glycolysis in Jurkat cells (IC50s = 1.6 and 0.847 μM

PFK158 – 25 mg

Brand:
Cayman
CAS:
1462249-75-7
Storage:
-20
UN-No:
Non-Hazardous - /

PFK158 is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3; IC50 = 137 nM for human recombinant PFKFB3).{37211} It inhibits PFKFB3 and glycolysis in Jurkat cells (IC50s = 1.6 and 0.847 μM, respectively). PFK158 inhibits the growth of leukemia cells in vitro (IC50 = 0.33 μM for Jurkat cells) and reduces tumor volume in CT-26 murine colon carcinoma syngeneic model and a BxPC-3 pancreatic cancer mouse xenograft model. PFK158 also enhances activity of the anti-CTLA-4 antibody in the B16/F10 mouse model of melanoma.{37212}  

 

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SKU: 22987 - 25 mg Category:

Description

A PFKFB3 inhibitor (IC50 = 137 nM for human recombinant PFKFB3); inhibits PFKFB3 and glycolysis in Jurkat cells (IC50s = 1.6 and 0.847 μM, respectively); inhibits the growth of leukemia cells in vitro (IC50 = 0.33 μM for Jurkat cells); reduces tumor volume in CT-26 murine colon carcinoma syngeneic model and a BxPC-3 pancreatic cancer mouse xenograft model; enhances activity of the anti-CTLA-4 antibody in the B16/F10 mouse model of melanoma

Formal name: 1-(4-pyridinyl)-3-[7-(trifluoromethyl)-2E-quinolinyl]-2-propen-1-one

Synonyms: 

Molecular weight: 328.3

CAS: 1462249-75-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Carbohydrate Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Cancer|Cell Signaling||Research Area|Cancer|Metabolism

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