A selective FAK inhibitor (IC50s = 4 and 30-100 nM for a purified recombinant catalytic fragment of FAK and in cultured cells

PF-573228 – 1 mg

Brand:
Cayman
CAS:
869288-64-2
Storage:
-20
UN-No:
Non-Hazardous - /

Focal adhesion kinases (FAKs) are non-receptor tyrosine kinases that play roles in regulating diverse processes, including cell adhesion, spreading, migration, proliferation, and apoptosis.{15630} They are overexpressed in many types of cancer. PF-573228 inhibits FAK with IC50 values of 4 and 30-100 nM for a purified recombinant catalytic fragment of FAK and in cultured cells, respectively.{14924} It is 50-250-fold selective for FAK over other protein kinases.{14924} PF-573228 can inhibit chemotactic and haptotactic migration of cells as well as prevent focal adhesion turnover.{28528}  

 

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Description

A selective FAK inhibitor (IC50s = 4 and 30-100 nM for a purified recombinant catalytic fragment of FAK and in cultured cells, respectively) that can inhibit chemotactic and haptotactic migration of cells as well as prevent focal adhesion turnover

Formal name: 3,4-dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone

Synonyms:  FAK Inhibitor II|Focal Adhesion Kinase Inhibitor II

Molecular weight: 491.5

CAS: 869288-64-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Non-Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area

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