An orally bioavailable broad-spectrum PI3K inhibitor (IC50s = 2

PF-4989216 – 25 mg

Brand:
Cayman
CAS:
1276553-09-3
Storage:
-20
UN-No:
Non-Hazardous - /

PF-4989216 is an orally bioavailable broad-spectrum PI3K inhibitor (IC50s = 2, 142, 65, 1, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively).{32573} It inhibits the cell viability of small-cell lung cancer (SCLC) cells with a mutation in PIK3CA, blocking PI3K downstream signaling and inducing apoptosis.{32573} PF-4989216 prevents tumor growth of SCLC cells harboring PIK3CA mutation in mice.{32573}  

 

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Description

An orally bioavailable broad-spectrum PI3K inhibitor (IC50s = 2, 142, 65, 1, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively)

Formal name: 4-(4-cyano-2-fluorophenyl)-2-(4-morpholinyl)-5-(1H-1,2,4-triazol-5-yl)-3-thiophenecarbonitrile

Synonyms: 

Molecular weight: 380.4

CAS: 1276553-09-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PI3K||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling

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