A dual inhibitor of FAK and PYK2 (IC50s = 2 and 11 nM

PF-431396 – 1 mg

Brand:
Cayman
CAS:
717906-29-1
Storage:
-20
UN-No:
Non-Hazardous - /

Proline-rich tyrosine kinase 2 (PYK2) and focal adhesion kinase (FAK) are nonreceptor tyrosine kinases that constitute the focal adhesion kinase subfamily. PYK2 is expressed in both bone-forming osteoblasts and bone-resorbing osteoclasts where it has a positive role in osteoclast maturation and bone resorption. PF-431396 is a pyrimidine-based dual inhibitor of FAK and PYK2 (IC50s = 2 and 11 nM, respectively).{28820} In ovariectomized rats, it has been shown to increase bone formation, promoting osteoblast recruitment and activity.{28821}  

 

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Description

A dual inhibitor of FAK and PYK2 (IC50s = 2 and 11 nM, respectively) that increases bone formation, promoting osteoblast recruitment and activity in ovariectomized rats

Formal name: N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-methanesulfonamide

Synonyms: 

Molecular weight: 506.5

CAS: 717906-29-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Non-Receptor Tyrosine Kinases||Product Type|Biochemicals|Kinase Inhibitors|SRC Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling

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