A potent and selective H+/K+-ATPase inhibitor; pIC50s = 6.026

PF-3716556 – 50 mg

Brand:
Cayman
CAS:
928774-43-0
Storage:
-20
UN-No:
Non-Hazardous - /

PF-3716556 is a potent and selective hydrogen-potassium pump (H+/K+-ATPase) inhibitor in a new class of acid suppressants, the potassium-competitive acid blockers or acid pump antagonists.{34027} PF-3716556 inhibited H+/K+-ATPase activity in porcine membrane vesicles, as well as canine and human recombinant cells under ion-leaky conditions (pIC50s = 6.026, 6.038, and 6.009, respectively). PF-3716556 showed 3-fold greater inhibition than revaprazan in ion-tight (neutral pH) conditions.  

 

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Description

A potent and selective H+/K+-ATPase inhibitor; pIC50s = 6.026, 6.038, and 6.009, respectively, for porcine membrane vesicles, and canine and human recombinant cells in ion-leaky (acidic) conditions; 3-fold greater inhibition than revaprazan in ion-tight conditions

Formal name: 8-[[(4R)-3,4-dihydro-5-methyl-2H-1-benzopyran-4-yl]amino]-N-(2-hydroxyethyl)-N,2-dimethyl-imidazo[1,2-a]pyridine-6-carboxamide

Synonyms: 

Molecular weight: 394.5

CAS: 928774-43-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area

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