Description
An inhibitor of γ-secretase (IC50s = 6.2 and 1.2 nM, respectively, in an enzyme assay and in whole cells); does not induce Notch-related toxicity (EC50s = 1,300-3,000 nM for B cells in fetal thymic organ cultures); reduces the level of Aβ40 fragments in mouse brain three hours following 1 to 18 mg/kg doses and the level of Aβ42 fragments levels at 9 or 18 mg/kg; reduces Aβ fragments when at 0.3-3 mg/kg per day for five days
Formal name: (2S)-2-[[(2S)-6,8-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]-pentanamide
Synonyms:
Molecular weight: 489.6
CAS: 1290543-63-3
Purity: ≥98%
Formulation: A solid
Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease
