An inhibitor of JAK1 and TYK2 (IC50s = 17 and 23 nM

PF-06700841 (tosylate) – 1 mg

Brand:
Cayman
CAS:
2140301-96-6
Storage:
-20
UN-No:
Non-Hazardous - /

PF-06700841 is an inhibitor of JAK1 and tyrosine kinase 2 (TYK2; IC50s = 17 and 23 nM, respectively).{44011} It is selective for JAK1 and TYK2 over JAK2 and JAK3 (IC50s = 77 and 6,494 nM, respectively). PF-06700841 selectively inhibits IFN-α/STAT3 signaling over erythropoietin/STAT5 signaling in human whole blood (IC50s = 30 and 577 nM, respectively). It reduces increases in hind paw volume in a rat model of adjuvant-induced arthritis in a dose-dependent manner.  

 

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SKU: 26125 - 1 mg Category:

Description

An inhibitor of JAK1 and TYK2 (IC50s = 17 and 23 nM, respectively); selective for JAK1 and TYK2 over JAK2 and JAK3 (IC50s = 77 and 6,494 nM, respectively); selectively inhibits IFN-α/STAT3 signaling over erythropoietin/STAT5 signaling in human whole blood (IC50s = 30 and 577 nM, respectively); reduces increases in hind paw volume in a rat model of adjuvant-induced arthritis in a dose-dependent manner

Formal name: [(1S)-2,2-difluorocyclopropyl][3-[2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-3,8-diazabicyclo[3.2.1]oct-8-yl]-methanone, 4-methylbenzenesulfonate

Synonyms: 

Molecular weight: 561.6

CAS: 2140301-96-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|JAK Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|JAK Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis

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