An inhibitor of ACC1 and 2 (IC50s = 27

PF-05175157 – 1 mg

Brand:
Cayman
CAS:
1301214-47-0
Storage:
-20
UN-No:
Non-Hazardous - /

PF-05175157 is an inhibitor of acetyl-CoA carboxylase 1 (ACC1) and ACC2 (IC50s = 27, 33, 23.5, and 50.4 nM for human ACC1, human ACC2, rat ACC1, and rat ACC2, respectively).{41717} It inhibits formation of malonyl-CoA in primary rat hepatocytes (EC50 = 29.9 nM). In vivo, PF-05175157 inhibits formation of malonyl-CoA in the liver and skeletal muscle, inhibits hepatic de novo lipogenesis, and lowers the respiratory exchange rate in rats (ED50s = 6, 11, 7.8, and 3.5 mg/kg, respectively).  

 

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Description

An inhibitor of ACC1 and 2 (IC50s = 27, 33, 23.5, and 50.4 nM for human ACC1, human ACC2, rat ACC1, and rat ACC2, respectively); inhibits formation of malonyl-CoA in primary rat hepatocytes (EC50 = 29.9 nM); inhibits formation of malonyl-CoA in the liver and skeletal muscle, inhibits hepatic de novo lipogenesis, and lowers the respiratory exchange rate in rats (ED50s = 6, 11, 7.8, and 3.5 mg/kg, respectively)

Formal name: 1,4-dihydro-1′-[(2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)-spiro[5H-indazole-5,4′-piperidin]-7(6H)-one

Synonyms: 

Molecular weight: 405.5

CAS: 1301214-47-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area

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