A partial agonist of the 5-HT4A

PF-04995274 – 5 mg

Brand:
Cayman
CAS:
1331782-27-4
Storage:
-20
UN-No:
Non-Hazardous - /

PF-04995274 is a partial agonist of the serotonin (5-HT) receptor subtypes 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E (Kis = 0.36, 0.46, 0.15, and 0.32 nM, respectively, in a radioligand binding assay).{52049} It increases cAMP levels in HEK293 cells expressing 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E receptors (EC50s = 0.47, 0.36, 0.37, and 0.26 nM, respectively, for the human recombinant receptors). PF-04995274 decreases scopolamine-induced increases in the distance traveled in the Morris water maze in rats when administered at a dose of 0.032 mg/kg.  

 

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SKU: 28776 - 5 mg Category:

Description

A partial agonist of the 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E receptors (Kis = 0.36, 0.46, 0.15, and 0.32 nM, respectively, in a radioligand binding assay); increases cAMP levels in HEK293 cells expressing 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E receptors (EC50s = 0.47, 0.36, 0.37, and 0.26 nM, respectively, for the human recombinant receptors); decreases scopolamine-induced increases in the distance traveled in the Morris water maze in rats at 0.032 mg/kg

Formal name: tetrahydro-4-[[4-[[[4-[[(3R)-tetrahydro-3-furanyl]oxy]-1,2-benzisoxazol-3-yl]oxy]methyl]-1-piperidinyl]methyl]-2H-pyran-4-ol

Synonyms: 

Molecular weight: 432.5

CAS: 1331782-27-4

Purity: ≥98%

Formulation: A crystalline solid

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