A selective

PF-04457845 – 10 mg

Brand:
Cayman
CAS:
1020315-31-4
Storage:
-20
UN-No:
Non-Hazardous - /

PF-04457845 is an orally active, irreversible inhibitor of fatty acid amide hydrolase (FAAH; IC50 = 7.2 nM) that is selective against other serine hydrolases.{20459} It is a covalent inhibitor that carbamylates the active site serine nucleophile of FAAH.{20459} In a rat model of inflammatory pain, oral administration of 0.1 mg/kg PF-04457845 has been shown to reduce inflammatory pain with efficacy comparable to that of naproxen.{20459}  

 

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Description

A selective, irreversible inhibitor of FAAH (IC50 = 7.2 nM); 0.1 mg/kg reduces inflammatory pain in a rat model

Formal name: N-3-pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide

Synonyms: 

Molecular weight: 455.4

CAS: 1020315-31-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Fatty Acid Metabolism||Research Area|Lipid Biochemistry|Endocannabinoid/Endocannabinoid-like||Research Area|Neuroscience|Pain Research

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