A modulator of voltage-gated sodium channels; 100-fold more potent at insect than mammalian sodium channels (500 nM); increases sodium influx in BV-2 microglial cells and primary by approximately 28 and 29%

Permethrin – 100 mg

Brand:
Cayman
CAS:
52645-53-1
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Permethrin is a modulator of voltage-gated sodium channels (NaV) that is used as an insecticide.{36375} It delays channel deactivation of the NaV1.8 channel expressed in X. laevis oocytes. It is at least 100-fold more potent at insect than mammalian sodium channels, leading to slow deactivation of D. para/TipE, but not rat brain IIA or β1, sodium channels expressed in X. laevis oocytes when used at a concentration of 500 nM.{36376} Permethrin (5 µM) increases sodium influx in BV-2 and primary microglial cells by approximately 28 and 29%, respectively, and activates microglia.{36377} Long-term application of permethrin leads to dose- and time-dependent intracellular sodium accumulation and TNF-α release in microglia in vitro. Formulations containing permethrin have been used for the treatment of head lice and scabies infestations.  

 

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Description

A modulator of voltage-gated sodium channels; 100-fold more potent at insect than mammalian sodium channels (500 nM); increases sodium influx in BV-2 microglial cells and primary by approximately 28 and 29%, respectively, and activates microglia (5 µM)

Formal name: 3-(2,2-dichloroethenyl)-2,2-dimethyl-cyclopropanecarboxylic acid, (3-phenoxyphenyl)methyl ester

Synonyms: 

Molecular weight: 391.3

CAS: 52645-53-1

Purity: ≥95% (mixture of isomers)

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation||Product Type|Biochemicals|Pesticides|Insecticides||Research Area|Neuroscience||Research Area|Toxicology|Environmental

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