An inhibitor of influenza neuraminidase (IC50s = 0.09 and 11 nM for influenza A and B neuraminidases

Peramivir – 5 mg

Brand:
Cayman
CAS:
330600-85-6
Storage:
-20
UN-No:
Non-Hazardous - /

Peramivir is an inhibitor of influenza neuraminidase (IC50s = 0.09 and 11 nM for influenza A and B neuraminidases, respectively).{41314} It is selective for influenza neuraminidase over bacterial, mammalian, and other viral neuraminidases (IC50s = >300 μM). Peramivir inhibits neuraminidase activity in H1N1, H2N2, H3N2, and H6N2 influenza strains (IC50s = 0.09-1.1 nM) and reduces lysis of MDCK cells infected with influenza (EC50s = <0.01-21 nM). Pretreatment with peramivir (10-100 mg/kg) protects mice against lethal influenza infections. It also increases survival in ferrets infected intranasally with avian influenza type A H5N1 when injected intramuscularly after infection.{41315} Formulations containing peramivir have been used to treat influenza.  

 

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Description

An inhibitor of influenza neuraminidase (IC50s = 0.09 and 11 nM for influenza A and B neuraminidases, respectively); selective for influenza neuraminidase over bacterial, mammalian, and other viral neuraminidases (IC50s = >300 μM); inhibits neuraminidase activity in H1N1, H2N2, H3N2, and H6N2 influenza strains (IC50s = 0.09-1.1 nM) and reduces lysis of MDCK cells infected with influenza (EC50s = <0.01-21 nM); protects mice against lethal influenza infections when administered prior to infection at a doses ranging from 10-100 mg/kg; increases survival in ferrets infected intranasally with avian influenza type A H5N1 when injected intramuscularly after infection

Formal name: (1S,2S,3R,4R)-3-[(1S)-1-(acetylamino)-2-ethylbutyl]-4-[(aminoiminomethyl)amino]-2-hydroxy-cyclopentanecarboxylic acid

Synonyms:  BCX 1812|RWJ 270201

Molecular weight: 328.4

CAS: 330600-85-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Neuraminidase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Influenza

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