A polypeptide released postprandially in proportion to meal energy content by endocrine L cells in the ileum and colon in order to regulate appetite; cleaved to PYY (3-36})

Peptide YY (3-36) – 500 µg

Brand:
Cayman
CAS:
123583-37-9
Storage:
-20
UN-No:
Non-Hazardous - /

Peptide YY (PYY) is a polypeptide that is released postprandially in proportion to meal energy content by endocrine L cells in the ileum and colon in order to regulate appetite.{24276} PYY, along with neuropeptide Y (NPY; Item No. 15071), inhibits gastrointestinal motility and electrolyte secretion, which is thought to indicate satiety through a potent feedback signal on hypothalamic circuits.{24276,27059} Upon release, PYY is cleaved to PYY (3-36), which is a preferred agonist at presynaptic inhibitory type 2 NPY autoreceptors (EC50 = 11.4 nM in human colon mucosa).{27058} PYY (3-36) has been associated with dose-dependent weight loss in various obesity models including ob/ob mice, diet-induced obese mice, and non-diabetic fatty Zucker rats.{27059}  

 

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Description

A polypeptide released postprandially in proportion to meal energy content by endocrine L cells in the ileum and colon in order to regulate appetite; cleaved to PYY (3-36}), a preferred agonist at presynaptic inhibitory type 2 NPY autoreceptors (EC50 = 11.4 nM in human colon mucosa); associated with dose-dependent weight loss in various obesity models

Formal name:

Synonyms:  Pancreatic Peptide YY|Peptide Tyrosine Tyrosine

Molecular weight: 4,049.50

CAS: 123583-37-9

Purity: ≥95%

Formulation: A lyophilized powder

Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Neuroscience|Neuroendocrinology

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