A PAM of AMPA receptors; selectively increases glutamate-induced currents in X. laevis oocytes expressing the flop isoforms of the AMPA receptor subunits GluR3 and GluR4 over the flip isoforms of these subunits at 200 µM; decreases the latency to find the platform in the Morris water maze

PEPA – 10 mg

Brand:
Cayman
CAS:
141286-78-4
Storage:
-20
UN-No:
Non-Hazardous - /

PEPA is a positive allosteric modulator (PAM) of AMPA receptors.{52115} It selectively increases glutamate-induced currents in X. laevis oocytes expressing the flop isoforms of the AMPA receptor subunits glutamate receptor 3 (GluR3) and GluR4 over the flip isoforms of these subunits at 200 µM. PEPA (10 mg/kg) decreases the latency to find the platform in the Morris water maze, indicating reversal of memory deficits, in a rat model of memory impairment induced by middle cerebral artery occlusion (MCAO).{52116} It decreases freezing time in a contextual fear freezing paradigm in mice when administered at a dose of 30 mg/kg.{52117}  

 

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Description

A PAM of AMPA receptors; selectively increases glutamate-induced currents in X. laevis oocytes expressing the flop isoforms of the AMPA receptor subunits GluR3 and GluR4 over the flip isoforms of these subunits at 200 µM; decreases the latency to find the platform in the Morris water maze, indicating reversal of memory deficits, in a rat model of memory impairment induced by MCAO at 10 mg/kg; decreases freezing time in a contextual fear freezing paradigm in mice at 30 mg/kg

Formal name: 2-[2,6-difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]-acetamide

Synonyms: 

Molecular weight: 402.4

CAS: 141286-78-4

Purity: ≥98%

Formulation: A crystalline solid

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