A purine nucleoside analog that irreversibly inhibits adenosine deaminase (Ki = 0.9 pM) and thus interrupts DNA synthesis in dividing cells; displays strong efficacy in the clinical treatment of hairy cell leukemia as well as relapsed chronic lymphocytic leukemia

Pentostatin – 10 mg

Brand:
Cayman
CAS:
53910-25-1
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Because of their antitumor activity via inhibition of DNA synthesis, purine nucleoside derivatives resistant to deamination have been developed for the treatment of various leukemias.{22555,21535} Pentostatin is a purine nucleoside analog that irreversibly inhibits adenosine deaminase (Ki = 0.9 pM) and thus interrupts DNA synthesis in dividing cells.{23726,23725} Pentostatin has been reported to display strong efficacy in the clinical treatment of hairy cell leukemia as well as relapsed chronic lymphocytic leukemia.{23725,21535}  

 

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Description

A purine nucleoside analog that irreversibly inhibits adenosine deaminase (Ki = 0.9 pM) and thus interrupts DNA synthesis in dividing cells; displays strong efficacy in the clinical treatment of hairy cell leukemia as well as relapsed chronic lymphocytic leukemia

Formal name: (8R)-3-(2-deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-imidazo[4,5-d][1,3]diazepin-8-ol

Synonyms:  CI 825|CL 67310465|DCF|Deoxycoformycin|NSC 218321|NSC 247520

Molecular weight: 268.3

CAS: 53910-25-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer|DNA Damage and Repair

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