A synthetic polypeptide and CCK2 receptor agonist; binds selectively to CCK2 in guinea pig brain over CCK1 receptors in rat pancreas (IC50s = 11 and 1

Pentagastrin – 100 mg

Brand:
Cayman
CAS:
5534-95-2
Storage:
-20
UN-No:
Non-Hazardous - /

Pentagastrin is a synthetic polypeptide and cholecystokinin-2 (CCK2) receptor agonist.{47672} It binds selectively to CCK2 receptors in guinea pig brain over CCK1 receptors in rat pancreas (IC50s = 11 and 1,100 nM, respectively). Pentagastrin increases calcium influx and polyphosphoinositide turnover in rat GH3 pituitary cells (EC50s = 23 and 3.9 nM, respectively). It also increases histidine decarboxylase activity in mucous- and endocrine cell-enriched isolated rabbit fundic mucosal cells (EC50 = 2.9 nM).{47673} Pentagastrin induces contraction of isolated pig ileum smooth muscle cells in vitro (EC50 = 30 pM).{47674} It increases gastric acid and pepsin secretion in conscious cats in vivo (ED50s = 1.29 and 57.3 nmol/kg2 per hour, respectively).{40719} Formulations containing pentagastrin have previously been used as a diagnostic aid to evaluate gastric acid secretory function.  

 

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SKU: 28546 - 100 mg Category:

Description

A synthetic polypeptide and CCK2 receptor agonist; binds selectively to CCK2 in guinea pig brain over CCK1 receptors in rat pancreas (IC50s = 11 and 1,100 nM, respectively); increases calcium influx and polyphosphoinositide turnover in rat GH3 pituitary cells (EC50s = 23 and 3.9 nM, respectively); increases histidine decarboxylase activity in mucous and endocrine cell-enriched isolated rabbit fundic mucosal cells (EC50 = 2.9 nM); induces contraction of isolated pig ileum smooth muscle cells in vitro (EC50 = 30 pM); increases gastric acid and pepsin secretion in conscious cats in vivo (ED50s = 1.29 and 57.3 nmol/kg2 per hour, respectively)

Formal name: N-[(1,1-dimethylethoxy)carbonyl]-β-alanyl-L-tryptophyl-L-methionyl-L-α-aspartyl-L-phenylalaninamide

Synonyms:  AY 6608|NSC 367746

Molecular weight: 767.9

CAS: 5534-95-2

Purity: ≥98%

Formulation: A solid

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